Predictive Diagnostics for Chronic Disorders Using Machine Learning

International Journal of Emerging Research in Science, Engineering, and Management
Vol. 2, Issue 4, pp. 103-108, April 2026.

https://doi.org/10.58482/ijersem.v2i4.14

Predictive Diagnostics for Chronic Disorders Using Machine Learning

S. Savitha, G. Jyothi Prakash, M. D. Prasannalakshmi, M. Karthik, B. Manojkumar

Department of CSE, Siddharth Institute of Engineering & Technology, Puttur, AP, India.

Abstract: : In recent years, the integration of Artificial Intelligence into healthcare has opened new avenues for early diagnosis and preventive care. This study presents a comprehensive web-based platform designed to predict multiple diseases, namely diabetes, heart disease, Parkinson’s disease, and breast cancer, using supervised machine learning algorithms. The system utilizes user-provided clinical parameters such as blood pressure, body mass index (BMI), glucose levels, age, and other relevant health indicators to generate accurate disease predictions. The backend prediction engine incorporates classification models, including Random Forest, Logistic Regression, and Support Vector Machine (SVM), trained and validated using publicly available medical datasets to ensure robustness and generalization. Unlike conventional single-disease prediction systems, the proposed framework provides multi-disease prediction within a unified interface, reducing the need for multiple diagnostic tools. The system also emphasizes interpretability by presenting prediction confidence scores and feature importance insights to improve transparency and reliability. The primary objective of the proposed framework is to support early disease detection and personalized healthcare through accessible predictive analytics, particularly in resource-limited regions. By combining machine learning-based predictive modeling with a user-friendly web interface, the system bridges the gap between computational intelligence and real-world clinical decision-making.

Keywords: Predictive Diagnostics, Chronic Disease Prediction, Random Forest, Logistic Regression, Healthcare Analytics.

References: 

  1. N. H. Zainal and N. Van Doren, “Sleep disturbances predict nine-year panic disorder chronicity: The sleep-panic nexus theory with machine learning insights,” Journal of Anxiety Disorders, vol. 114, p. 103052, Jul. 2025, doi: 10.1016/j.janxdis.2025.103052.S.
  2. Cheng et al., “A machine learning approach to predicting postoperative recurrence in pediatric chronic rhinosinusitis: identification of key metabolic biomarkers,” American Journal of Otolaryngology, vol. 46, no. 5, p. 104676, May 2025, doi: 10.1016/j.amjoto.2025.104676.
  3. L. Liang, T. Liu, W. Ollier, Y. Peng, Y. Lu, and C. Che, “Identifying new risk associations between chronic physical illness and mental health disorders in China: Machine Learning approach to a Retrospective Population analysis,” JMIR AI, vol. 4, p. e72599, Apr. 2025, doi: 10.2196/72599.
  4. M. Olenik and H. M. Dönertaş, “Machine learning and OMIC data for prediction of health and chronic diseases,” in Elsevier eBooks, 2025, pp. 365–388. doi: 10.1016/b978-0-323-95502-7.00284-0.
  5. K. Matsumura, K. Hamazaki, H. Kasamatsu, A. Tsuchida, and H. Inadera, “Decision tree learning for predicting chronic postpartum depression in the Japan Environment and Children’s Study,” Journal of Affective Disorders, vol. 369, pp. 643–652, Oct. 2024, doi: 10.1016/j.jad.2024.10.034.
  6. N. Almusallam and S. Khan, “Chronic liver disease classification using deep learning with SHAP-optimized hybrid features,” iScience, vol. 28, no. 12, p. 113972, Nov. 2025, doi: 10.1016/j.isci.2025.113972.
  7. F. Zmudzki, R. J. E. M. Smeets, J. S. Groenewegen, and E. Van Der Graaff, “Machine Learning Clinical decision support for interdisciplinary multimodal chronic musculoskeletal pain treatment: Prospective Pilot Study of patient assessment and Prognostic Profile validation,” JMIR Rehabilitation and Assistive Technologies, vol. 12, p. e65890, Feb. 2025, doi: 10.2196/65890.
  8. M. A. Shahbazi, M. A. Al-Mamun, T. Brothers, and I. Ahmed, “A machine learning framework for identifying phenotypes in chronic kidney disease,” Healthcare Analytics, vol. 8, p. 100425, Oct. 2025, doi: 10.1016/j.health.2025.100425.
  9. J. Yang et al., “Machine learning-based risk prediction of mild cognitive impairment in patients with chronic heart failure: A model development and validation study,” Geriatric Nursing, vol. 62, no. Pt A, pp. 145–156, Feb. 2025, doi: 10.1016/j.gerinurse.2025.01.022.
  10. J. M and A. N, “Conceptual metaphor quantum correlation and radial basis extreme learning for predicting chronic kidney disease,” Computers & Electrical Engineering, vol. 122, p. 109933, Dec. 2024, doi: 10.1016/j.compeleceng.2024.109933.
  11. L. Mauvieux et al., “Artificial intelligence–based flow cytometry for the diagnosis of B-cell chronic lymphoproliferative disorders,” Blood Advances, vol. 9, no. 22, pp. 5880–5887, Nov. 2025, doi: 10.1182/bloodadvances.2025016424.
  12. D. S. Khafaga, N. Khodadadi, E. Khodadadi, A. A. Alhussan, M. M. Eid, and E.-S. M. El-Kenawy, “Enhanced early chronic kidney disease prediction using hybrid waterwheel plant algorithm for deep neural network optimization,” Scientific Reports, vol. 15, no. 1, p. 42584, Nov. 2025, doi: 10.1038/s41598-025-26382-6.